職務名稱：Postdoctoral Fellow (Job ref: R1637)

系所/單位名稱： Yardimci lab - Single Molecule Imaging of Genome Duplication and Maintenance Laboratory

申請人資格：

The Research Group

Our laboratory investigates processes involved in eukaryotic DNA replication and genome maintenance using conventional biochemistry and single-molecule visualization tools. To study eukaryotic replication, we use a number of model systems including Xenopus egg extracts and a reconstituted system with purified human proteins. The group currently consists of around 6 researchers including PhD students, postdoctoral fellows and laboratory research scientists. For more information, please see the laboratory website.

The Project

We aim to unravel the intricate mechanisms of eukaryotic DNA replication machinery as it maneuvres through the chromatin landscape, shedding light on the processes that ensure accurate genome duplication. Employing the precision of single-molecule fluorescence microscopy, we can observe replisome dynamics unfold in real time. Previous work in our lab has shed light on the interplay between DNA replication and essential chromatin processes, including parental histone recycling (Gruszka et al, 2019. Sci Adv) and the establishment of sister chromatid cohesion (Cameron et al, 2024. Science). Building on these foundations, our current project seeks to elucidate the molecular intricacies of these interactions, potentially revolutionizing our understanding of genomic fidelity.

The Postdoctoral Fellow will lead their own projects, contribute to other projects in the lab and may guide PhD students in their research. They will have the opportunity to present their work at international conferences and partake in interdisciplinary collaborations that will expand both knowledge and professional networks. Therefore, the ability to work in a team is essential.

Essential

PhD (including but not limited biochemistry and biophysics) or in the final stages of PhD submission

Strong interest in genome maintenance

Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals

Evidence of data presentation at scientific meetings

Excellent organisational and communication skills

Ability to work independently and also capable of interacting within a group

聘期：This is a full-time, fixed term 4 years position on Crick terms and conditions of employment.

薪資待遇：From £43,210, subject to skills and experience.

受理期間：2024年5月23日止

相關細節請參考網址：https://www.crick.ac.uk/careers-study/vacancies/2024-04-24-postdoctoral-fellow