The main mission of the Science and Technology Division, STD/France, is to establish and oversee scientific collaborative relationships between Taiwan and France, as well as Spain, Italy, and Portugal.

STD/France serves as the official liaison between the Taiwanese government and the governments of France, Spain, Italy, and Portugal concerning research and technology affairs.

Additionally, STD/France is tasked with promoting existing agreements, such as Memorandums of Understanding (MOUs), signed between the National Science and Technology Council (NSTC) of Taiwan and prominent French research agencies and institutes such as ANR, CNRS, INRIA, INSERM, INCa, HERCULES, and the Académie des Sciences (Ads). Similar collaborations are pursued with institutions such as CSIC in Spain and CNR in Italy. The division facilitates exchange visits, fosters collaborative initiatives, and oversees the progress of ongoing research projects.

Moreover, STD/France aims to forge new collaborative ties between Taiwanese research institutes and other esteemed foreign research establishments, including IFREMER, CNES, Institut Pasteur, CEA, and AI/Quantum-related research centers. The division actively promotes bilateral research visits and supports joint seminar funding. These endeavors may culminate in the signing of scientific bilateral cooperation agreements in the near future.