職務名稱：Higher Scientific Officer - Assay Development and Compound Profiling
系所/單位名稱：The Hit Discovery and Structural Design Team - Dr Caroline Ewens
申請人資格：
Under the guidance of Dr Caroline Ewens, we are seeking a highly motivated scientist keen to apply small molecule screening science expertise to help progress our cancer drug discovery projects from assay development and hit finding to candidate selection. The successful candidate will develop and run plate-based biochemical and/or cellular screening assays to support the identification and characterisation of small-molecule inhibitors against novel cancer targets using a variety of detection technologies. The successful candidate will be embedded in the Hit Discovery and Structural Design Team but work with multidisciplinary teams.
About you
Key requirements for the role are significant and broad all-round laboratory experience monitoring small molecule binding and function applied to drug discovery. A good understanding of enzymology would be beneficial, as would prior use of automation equipment for liquid and compound handling used in compound profiling.
Department/Directorate Information
The Hit Discovery and Structural Design Team uses biochemical, cellular and biophysical assays to perform small-molecule high-throughput screening and fragment-based hit discovery, coupled with X-ray crystallography and electron microscopy to enable structure-based drug design within the CCDD. These methodologies are underpinned by state-of-the-art protein expression, purification and characterisation capabilities, allowing for the generation of large quantities of high-quality protein targets.
You will be joining a team working at the crossroads of the drug discovery activities of the CCDD, where scientific excellence and team science are core values. This position will also offer training in new techniques and support will be available for attending training courses and appropriate academic meetings.
聘期：Fixed Term for 18 months initially
薪資待遇：Commencement on the salary range is subject to comparable skills and experience.
受理期間：2026年2月8日止 (We reserve the right to close this vacancy early before the closing date if enough applications are received.)
