職務名稱：Postdoctoral Fellow
系所/單位名稱：Chudnovskiy Lab
申請人資格：
The Research Group
The laboratory of Tumour-Immune Communication has been established in early 2024. We study bidirectional interactions between cancer cells and the host immune system using synthetic and molecular biology, genetics, and immunology. This research delineates how interaction dynamics between tumour cells and immune cells influence each other, contributing to our understanding of tumour progression and antitumour immune response.
The Project
This project is designed to understand the interactions between tumour cells and immune cells utilising a variety of tumour cell lines and genetic models, with a primary but not exclusive focus on lung cancer and lung metastases. Our laboratory is equipped to track tumour-immune interactions at the single cell level. The LIPSTIC system—Labeling Immune Partnerships by SorTagging Intercellular Contacts—is used to unravel the cellular communication within the tumour microenvironment, concentrating on the interactions between tumour cells and immune cells, as well as between different antigen-presenting cells and T cells. The postdoctoral researcher will employ advanced genetic and molecular biology techniques as well as a lot of scRNA-seq to investigate the principles that govern the dynamics of tumour-immune interactions, aiming to apply this understanding to the development of cancer treatments. The work will involve the study of a wide range of tumour models, with an emphasis on lung cancer and other cancers that metastasise to the lung. The initial phase of the project will characterise the nature of tumour-immune interactions during steady-state tumour growth and after therapeutic interventions. In the later stages, the project is likely to evolve into a detailed mechanistic study of the interactions between specific immune cell populations and tumour cells. The ultimate goal is to utilise the findings from these studies to enhance therapeutic approaches for cancer.
Essential
- PhD in immunology, cancer biology, molecular or cellular biology or in the final stages of PhD submission
- Good knowledge and experience in immunology and/or tumor biology and/or molecular or cellular biology
- Technical expertise in basic immunological and/or molecular and/or cellular biology techniques.
- Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
- Evidence of data presentation at scientific meetings
聘期：This is a full time 4-year position on Crick terms and conditions of employment.
薪資待遇：From £43,210, subject to skills and experience.
受理期間：2024年5月12日止
相關細節請參考網址：https://www.crick.ac.uk/careers-study/vacancies/2024-03-13-postdoctoral-fellow-chudnovskiy-lab
