職務名稱：Postdoctoral Research Scientist
系所/單位名稱：Dr Jon Houseley group
申請人資格：
We are seeking a Postdoctoral Research Scientist to join the Houseley group at the Babraham Institute, Cambridge to work on metabolic and genetic dysregulation in ageing.
This BBSRC-funded post addresses the fundamental mechanisms of ageing. Our lab asks why progressive loss of fitness is associated with organismal ageing and whether we can prevent this decline to achieve ‘healthy ageing’. We are particularly focused on the ageing genome and epigenome, asking why and how these change in a slow, progressive manner with age, and linking these changes to metabolic dysfunction. We have recently demonstrated that rewiring of acetyl coenzyme A metabolism, which is critical for epigenetic state and DNA repair as well as fatty acid provision, allows yeast cells to maintain full fitness to the end of life (see our bioRxiv manuscript). Excitingly, this rewiring involves highly conserved pathways and we now have both mouse mutants and human ESC cells ready to test how equivalent metabolic changes influence ageing and response to diet in mammals. Analysing these mutants will be the initial aim for this PDRA position, utilising a wide variety of molecular methods, with a particular focus on sequencing methods in which we have a particular specialisation.
This position would suit a candidate with a background in mechanistic studies of metabolism, epigenetics or DNA biology and experience with using mice as a model system. Experience in analysis of high throughput data would be a major advantage (not necessarily sequencing – metabolomic or proteomic skills would be a useful addition to the lab), and a keen interest in ageing research will be vital.
The postdoctoral Scientist will play a key role in the work of the Research Group, through theconduct of research, introduction of new ideas, dissemination of research results, support and training of others. The successful applicant will lead projects translating the outcomes of our cellular ageing research into animals and physiologically relevant cell culture models. We have recently demonstrated that the metabolism of yeast cells can be re-designed such that they remain healthy for their whole life (bioRxiv manuscript) and now have equivalent mutants in both mouse and human ESC models, making this a particularly exciting time to join our team. This will require an excellent knowledge of cell and molecular biology and proficiency with mouse models, as well as an enthusiasm for understanding the molecular drivers of ageing.
聘期：Fixed Term, 3 years in the first instance
薪資待遇：£37,364 to £44,614 per annum (depending on number of years post PhD experience)
受理期間：2026年2月10日止 (We may close the vacancy early if we receive enough applications, so please apply as soon as possible.)
相關細節請參考網址：https://babrahaminstitute.livevacancies.co.uk/#/job/details/515
